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<p>Dairy cow health involves host-microbiome interactions. This review characterized microbial landscapes across anatomical sites in dairy cows—including the gastrointestinal tract, respiratory system, reproductive tract, mammary gland, and skin—and examines their associations with diseases. We elucidated how site-specific dysbiosis drives systemic conditions such as mastitis and ketosis through inter-organ axes. Finally, we evaluated emerging microbiome-based modulation strategies and their application prospects in dairy farming.</p>

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Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月17日

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  • Pei Zhong,
  • Ao Ren,
  • Junwei Cui,
  • Cheng Guo,
  • Yanmei Zhang,
  • Qiyu Diao,
  • Xianjun Liu,
  • Naifeng Zhang,
  • Yan Tu,
  • Yanliang Bi

摘要

Dairy cow health involves host-microbiome interactions. This review characterized microbial landscapes across anatomical sites in dairy cows—including the gastrointestinal tract, respiratory system, reproductive tract, mammary gland, and skin—and examines their associations with diseases. We elucidated how site-specific dysbiosis drives systemic conditions such as mastitis and ketosis through inter-organ axes. Finally, we evaluated emerging microbiome-based modulation strategies and their application prospects in dairy farming.