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<p>Chronic liver disease (CLD) causes 2 million annual deaths (4% of all global deaths). While gut bacteria are widely studied, intestinal fungi remain largely overlooked despite their critical roles in maintaining microecological homeostasis. This review summarizes fungal characteristics in alcohol-related liver disease, metabolic dysfunction-associated steatotic liver disease, primary sclerosing cholangitis, and cirrhosis, analyzing roles of fungi and their metabolites. Targeting the gut fungal community may offer therapeutic strategies for CLD.</p><p></p>

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The role and possible mechanism of intestinal fungi in the progression of chronic liver diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月10日

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  • Yirui Hu,
  • Ye Yang,
  • Shuyan Wang,
  • Huikuan Chu

摘要

Chronic liver disease (CLD) causes 2 million annual deaths (4% of all global deaths). While gut bacteria are widely studied, intestinal fungi remain largely overlooked despite their critical roles in maintaining microecological homeostasis. This review summarizes fungal characteristics in alcohol-related liver disease, metabolic dysfunction-associated steatotic liver disease, primary sclerosing cholangitis, and cirrhosis, analyzing roles of fungi and their metabolites. Targeting the gut fungal community may offer therapeutic strategies for CLD.