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<p>Socioeconomic status (SES) correlates with adverse health outcomes, but the underlying biological mechanisms remain unclear. We examined how area-level deprivation (Townsend Deprivation Index) influences gut microbiome composition and function and whether the gut microbiome mediates the effects of deprivation on metabolic and mental health. A total of 1390 females from TwinsUK with shotgun metagenomes were included in this study. We found that higher Townsend deprivation was associated with reduced alpha diversity (Beta [95% CI] = −1.60 [−3.00, −0.21]) and distinct microbial composition shifts (PERMANOVA <i>P</i> = 0.001). Twelve species and 22 functional pathways were linked to deprivation, distinguishing between deprivation groups (AUC = 0.725–0.744), with altered energy metabolism in deprived individuals. Townsend deprivation was associated with anxiety (OR [95%CI] = 1.09 [1.01, 1.18]) and diabetes (OR [95% CI] = 1.16 [1.03, 1.30]). Importantly, <i>Intestinimonas massiliensis</i> and <i>Lawsonibacter sp_NSJ_51</i> partially mediate the effect of anxiety. <i>Lawsonibacter sp_NSJ_51</i> also mediated the deprivation-diabetes association. These findings suggest that socioeconomic deprivation influences microbiome composition and function, mediating disparities in metabolic and mental health.</p>

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Gut microbiome composition and function reflect socioeconomic deprivation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • Yu Lin,
  • Afroditi Kouraki,
  • Nathan J. Cheetham,
  • Panayiotis Louca,
  • Ruth CE Bowyer,
  • Robert Pope,
  • Francesco Asnicar,
  • Xinyuan Zhang,
  • Alessia Visconti,
  • Mario Falchi,
  • Tim D. Spector,
  • Nicola Segata,
  • Ana M. Valdes,
  • Cristina Menni

摘要

Socioeconomic status (SES) correlates with adverse health outcomes, but the underlying biological mechanisms remain unclear. We examined how area-level deprivation (Townsend Deprivation Index) influences gut microbiome composition and function and whether the gut microbiome mediates the effects of deprivation on metabolic and mental health. A total of 1390 females from TwinsUK with shotgun metagenomes were included in this study. We found that higher Townsend deprivation was associated with reduced alpha diversity (Beta [95% CI] = −1.60 [−3.00, −0.21]) and distinct microbial composition shifts (PERMANOVA P = 0.001). Twelve species and 22 functional pathways were linked to deprivation, distinguishing between deprivation groups (AUC = 0.725–0.744), with altered energy metabolism in deprived individuals. Townsend deprivation was associated with anxiety (OR [95%CI] = 1.09 [1.01, 1.18]) and diabetes (OR [95% CI] = 1.16 [1.03, 1.30]). Importantly, Intestinimonas massiliensis and Lawsonibacter sp_NSJ_51 partially mediate the effect of anxiety. Lawsonibacter sp_NSJ_51 also mediated the deprivation-diabetes association. These findings suggest that socioeconomic deprivation influences microbiome composition and function, mediating disparities in metabolic and mental health.