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<p>This study investigated the relationship between constipation and autism-related symptoms in children with autism spectrum disorder (ASD). Participants were assessed for gastrointestinal (GI) and autism-related symptoms and classified into constipated and non-constipated groups. The relationship was further explored via 16S rRNA sequencing and non-targeted metabolomics to identify underlying mechanisms. Results revealed that constipated ASD children exhibited more severe autism-related symptoms and alterations in four bacterial taxa—the phylum Bacteroidetes, the family Barnesiellaceae, and the genera <i>Alistipes</i> and <i>Bilophila</i>—plus 451 metabolites compared to non-constipated ASD children. Among the altered bacterial taxa, three—Bacteroidetes, <i>Alistipes</i>, and <i>Bilophila</i>—exacerbated the relationship between constipation and autism-related symptoms. Five metabolites derived from the above three taxa—chenodeoxycholic acid, palmitic acid, glutaric acid, arachidonic acid, and choline—were significantly associated with autism-related symptoms. Our multi-omics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with ASD.</p>

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Multiomics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with autism spectrum disorder

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月8日

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  • Hailin Li,
  • Xiuhong Li,
  • Xin Wang,
  • Lizi Lin,
  • Muqing Cao,
  • Shuolin Pan,
  • Xiaoxuan Ou,
  • Tingfeng Gu,
  • Shuli Shen,
  • Hailin Li,
  • Jin Jing

摘要

This study investigated the relationship between constipation and autism-related symptoms in children with autism spectrum disorder (ASD). Participants were assessed for gastrointestinal (GI) and autism-related symptoms and classified into constipated and non-constipated groups. The relationship was further explored via 16S rRNA sequencing and non-targeted metabolomics to identify underlying mechanisms. Results revealed that constipated ASD children exhibited more severe autism-related symptoms and alterations in four bacterial taxa—the phylum Bacteroidetes, the family Barnesiellaceae, and the genera Alistipes and Bilophila—plus 451 metabolites compared to non-constipated ASD children. Among the altered bacterial taxa, three—Bacteroidetes, Alistipes, and Bilophila—exacerbated the relationship between constipation and autism-related symptoms. Five metabolites derived from the above three taxa—chenodeoxycholic acid, palmitic acid, glutaric acid, arachidonic acid, and choline—were significantly associated with autism-related symptoms. Our multi-omics analysis reveals the exacerbating effect of constipation on autism-related symptoms in children with ASD.