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<p>Constipation is a prevalent gastrointestinal disorder associated with alterations in the gut microbiota. However, the potential microbial targets and their underlying mechanisms remain to be explored. Our analysis found the genus <i>Ruminococcus</i> was depleted in constipated patients. We then tested four species, <i>R. bromii</i>, <i>R. torques</i>, <i>R. obeum</i>, and <i>R. gnavus</i>, in constipated mice, finding all alleviated symptoms. <i>R. bromii</i> was most effective, with its pullulanase enzyme being key to degrading resistant starch. This degradation boosted short-chain fatty acid production and fostered beneficial bacteria like <i>Akkermansia</i> and <i>Bifidobacterium</i>. A subsequent clinical trial confirmed that the constipation-relieving effect of dietary resistant starch was dependent on the presence and abundance of <i>R. bromii</i> in the gut. This study identifies <i>R. bromii</i> as a key microbial mediator for constipation relief through resistant starch metabolism, positioning it as a promising candidate for targeted probiotic or synbiotic therapies.</p>

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Ruminococcus bromii alleviates constipation by pullulanase-driven resistant starch degradation and microbiota modulation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月14日

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  • Rong Li,
  • Qianqian Yang,
  • Junqing He,
  • Min Li,
  • Qiang Ding,
  • Kun Tian,
  • Wei Yang,
  • Guoxing Zhang,
  • Aihua Guo,
  • Man Gu,
  • Qin Yu,
  • Haidong Jia,
  • Dezheng Xu,
  • Hongju Yang,
  • Huaping Xie,
  • Weihua Chen,
  • Zhi Liu

摘要

Constipation is a prevalent gastrointestinal disorder associated with alterations in the gut microbiota. However, the potential microbial targets and their underlying mechanisms remain to be explored. Our analysis found the genus Ruminococcus was depleted in constipated patients. We then tested four species, R. bromii, R. torques, R. obeum, and R. gnavus, in constipated mice, finding all alleviated symptoms. R. bromii was most effective, with its pullulanase enzyme being key to degrading resistant starch. This degradation boosted short-chain fatty acid production and fostered beneficial bacteria like Akkermansia and Bifidobacterium. A subsequent clinical trial confirmed that the constipation-relieving effect of dietary resistant starch was dependent on the presence and abundance of R. bromii in the gut. This study identifies R. bromii as a key microbial mediator for constipation relief through resistant starch metabolism, positioning it as a promising candidate for targeted probiotic or synbiotic therapies.