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<p>Optimizing chemotherapy for breast cancer (BC) remains a critical challenge. Gut microbiota (GM) dysbiosis, varying across BC subtypes and stages, influences BC development and chemotherapy response through immune and metabolic pathways. Chemotherapy also disrupts the microbiota, creating a complex bidirectional interaction. Integrating artificial intelligence (AI) allows the identification of hidden patterns, deepening our understanding of the microbiota’s role. This integrated approach promises to revolutionize BC treatment with novel insights and personalized interventions.</p>

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Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月9日

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  • Yi Zhou,
  • Min Jiang,
  • Ke Shen,
  • Tao He,
  • Siyu Zhou,
  • Aibin Shao,
  • Xiaoyu Li,
  • Jiao Wang,
  • Rongrong Wu,
  • Rajeev K. Singla,
  • Jonathan P. Jacobs,
  • Bairong Shen

摘要

Optimizing chemotherapy for breast cancer (BC) remains a critical challenge. Gut microbiota (GM) dysbiosis, varying across BC subtypes and stages, influences BC development and chemotherapy response through immune and metabolic pathways. Chemotherapy also disrupts the microbiota, creating a complex bidirectional interaction. Integrating artificial intelligence (AI) allows the identification of hidden patterns, deepening our understanding of the microbiota’s role. This integrated approach promises to revolutionize BC treatment with novel insights and personalized interventions.