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<p>Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.</p>

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Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月1日

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  • Esmée Grundeken,
  • Sahar El Aidy

摘要

Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.