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<p><i>Pseudomonas aeruginosa</i> biofilms contribute to chronic infections by resisting immune attacks and antibiotics. This review explores how innate immunity, including neutrophils, macrophages, and dendritic cells, responds to biofilms and how adaptive mechanisms involving T cells, B cells, and immunoglobulins contribute to infection persistence. Additionally, it highlights immune evasion strategies and discusses emerging therapies such as immunotherapy, monoclonal antibodies, and vaccines, offering insights into enhancing biofilm clearance and improving treatment outcomes.</p>

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Immune system dynamics in response to Pseudomonas aeruginosa biofilms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月12日

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  • Abhijeet Sahu,
  • Rohit Ruhal

摘要

Pseudomonas aeruginosa biofilms contribute to chronic infections by resisting immune attacks and antibiotics. This review explores how innate immunity, including neutrophils, macrophages, and dendritic cells, responds to biofilms and how adaptive mechanisms involving T cells, B cells, and immunoglobulins contribute to infection persistence. Additionally, it highlights immune evasion strategies and discusses emerging therapies such as immunotherapy, monoclonal antibodies, and vaccines, offering insights into enhancing biofilm clearance and improving treatment outcomes.