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<p>Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of <i>[Ruminococcus] gnavus</i> mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. <i>[Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens</i> were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism.</p>

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Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月28日

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  • Lijun Zeng,
  • Bin Yu,
  • Peibin Zeng,
  • Zhuoma Duoji,
  • Haojiang Zuo,
  • Jian Lian,
  • Tingting Yang,
  • Yingxue Dai,
  • Yuemei Feng,
  • Peng Yu,
  • Jiqi Yang,
  • Shujuan Yang,
  • Qingyu Dou

摘要

Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of [Ruminococcus] gnavus mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. [Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism.