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<p>The infant gut microbiome is essential for long-term health and is linked to atopic dermatitis (AD), although the underlying mechanisms are not fully understood. This study investigated gut microbiome-host interactions in 31 infants with AD and 29 healthy controls using multi-omics approaches, including metagenomic, host transcriptomic, and metabolomic analyses. Microbial diversity was significantly altered in AD, with <i>Bifidobacterium longum</i> and <i>Clostridium innocuum</i> associated with these changes. At the strain-level, only <i>B. longum</i> differed significantly between groups, with pangenome analyses identifying genetic variations potentially affecting amino acid and lipid metabolites. Notably, <i>B. longum</i> subclade I, which was more prevalent in healthy controls, correlated with host transcriptomic pathways involved in phosphatidylinositol 3-kinase-AKT signaling and neuroactive ligand-receptor pathways, as well as specific metabolites, including tetrahydrocortisol and ornithine. These findings highlight the role of <i>B. longum</i> strain-level variation in infants, offering new insights into microbiome-host interactions related to AD.</p>

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Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月29日

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  • Hoon Je Seong,
  • Yoon Mee Park,
  • Bong-Soo Kim,
  • Hyun Ju Yoo,
  • Taeyune Kim,
  • Sun Mi Yoon,
  • Jeong-Hyun Kim,
  • So-Yeon Lee,
  • Yun Kyung Lee,
  • Dong-Woo Lee,
  • Myung Hee Nam,
  • Soo-Jong Hong

摘要

The infant gut microbiome is essential for long-term health and is linked to atopic dermatitis (AD), although the underlying mechanisms are not fully understood. This study investigated gut microbiome-host interactions in 31 infants with AD and 29 healthy controls using multi-omics approaches, including metagenomic, host transcriptomic, and metabolomic analyses. Microbial diversity was significantly altered in AD, with Bifidobacterium longum and Clostridium innocuum associated with these changes. At the strain-level, only B. longum differed significantly between groups, with pangenome analyses identifying genetic variations potentially affecting amino acid and lipid metabolites. Notably, B. longum subclade I, which was more prevalent in healthy controls, correlated with host transcriptomic pathways involved in phosphatidylinositol 3-kinase-AKT signaling and neuroactive ligand-receptor pathways, as well as specific metabolites, including tetrahydrocortisol and ornithine. These findings highlight the role of B. longum strain-level variation in infants, offering new insights into microbiome-host interactions related to AD.