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<p>Emerging evidence links oral-derived gut microbes to colorectal cancer (CRC) development, but CRC prognosis-related microbial alterations in oral remain underexplored. In a retrospective study of 312 CRC patients, we examined the oral microbiota using 16S rRNA gene full-length amplicon sequencing to identify prognostic microbial biomarkers for CRC. <i>Neisseria oralis</i> and <i>Campylobacter gracilis</i> increased CRC progression risk (HR = 2.63 with <i>P</i> = 0.007, HR = 2.27 with <i>P</i> = 0.001, respectively), while <i>Treponema medium</i> showed protective effects (HR = 0.41, <i>P</i> = 0.0002). A microbial risk score (MRS) incorporating these species effectively predicted CRC progression risk (C-index = 0.68, 95% CI = 0.61–0.76). When compared to a model constructed solely from clinical factors, including tumor stage, lymphatic metastasis, and perineural invasion, the predictive accuracy significantly improved with the addition of the MRS, resulting in a C-index rising to 0.77 (<i>P</i> = 2.33 × 10<sup>−5</sup>). Our findings suggest that oral microbiota biomarkers may contribute to personalized CRC monitoring strategies, their implementation in clinical surveillance necessitates confirmatory studies.</p>

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Oral microbiota signature predicts the prognosis of colorectal carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月5日

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  • Shi-Hao Zhou,
  • Yan Du,
  • Wen-Qiong Xue,
  • Min-Jun He,
  • Ting Zhou,
  • Zhi-Yang Zhao,
  • Lu Pei,
  • Yi-Wei Chen,
  • Jin-Ru Xie,
  • Chang-Ling Huang,
  • Yong-Qiao He,
  • Tong-Min Wang,
  • Ying Liao,
  • Wei-Hua Jia

摘要

Emerging evidence links oral-derived gut microbes to colorectal cancer (CRC) development, but CRC prognosis-related microbial alterations in oral remain underexplored. In a retrospective study of 312 CRC patients, we examined the oral microbiota using 16S rRNA gene full-length amplicon sequencing to identify prognostic microbial biomarkers for CRC. Neisseria oralis and Campylobacter gracilis increased CRC progression risk (HR = 2.63 with P = 0.007, HR = 2.27 with P = 0.001, respectively), while Treponema medium showed protective effects (HR = 0.41, P = 0.0002). A microbial risk score (MRS) incorporating these species effectively predicted CRC progression risk (C-index = 0.68, 95% CI = 0.61–0.76). When compared to a model constructed solely from clinical factors, including tumor stage, lymphatic metastasis, and perineural invasion, the predictive accuracy significantly improved with the addition of the MRS, resulting in a C-index rising to 0.77 (P = 2.33 × 10−5). Our findings suggest that oral microbiota biomarkers may contribute to personalized CRC monitoring strategies, their implementation in clinical surveillance necessitates confirmatory studies.