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<p>Sjögren’s syndrome (SS) is a prevalent systemic autoimmune disease with substantial impacts on women’s health worldwide. Although oral <i>Haemophilus parainfluenzae</i> is reduced in SS, its significance remains unclear. This study aimed to elucidate the pathophysiological role of <i>H. parainfluenzae</i> in SS. Reduced salivary <i>H. parainfluenzae</i> levels in SS patients were confirmed through quantitative PCR. Oral <i>H. parainfluenzae</i> inoculation in NOD mice alleviated focal sialadenitis, improved salivary function, and reduced IFN-γ<sup>+</sup>CD3<sup>+</sup> and IFN-γ<sup>+</sup>CD8<sup>+</sup> T cells in salivary gland-draining lymph nodes, maintaining immune homeostasis against a biased type 1 response. Inoculation also enhanced salivary microbiota diversity, balanced the Firmicutes-to-Proteobacteria ratio, and reduced the overwhelming presence of <i>Pseudomonas mendocina</i>. In vitro, <i>H. parainfluenzae</i>-preconditioned A253 cells limited CD8 T cell expansion with reduced IFN-γ production. These findings suggest that <i>H. parainfluenzae</i> improves oral microbial diversity, promotes homeostatic T-cell immunity, and protects against SS, supporting its potential as a next-generation probiotic.</p>

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A human oral commensal-mediated protection against Sjögren’s syndrome with maintenance of T cell immune homeostasis and improved oral microbiota

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月16日

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  • Yu-Chao Tseng,
  • Kai-Sheng Liao,
  • Wei-ting Lin,
  • Chin Li,
  • Chia-Bin Chang,
  • Jie-Wei Hsu,
  • Chin-Pui Chan,
  • Chun-Ming Chen,
  • Hon-Pin Wang,
  • Hsiu-Chuan Chien,
  • Jann-Tay Wang,
  • Song-Chou Hsieh,
  • Shu-Fen Wu

摘要

Sjögren’s syndrome (SS) is a prevalent systemic autoimmune disease with substantial impacts on women’s health worldwide. Although oral Haemophilus parainfluenzae is reduced in SS, its significance remains unclear. This study aimed to elucidate the pathophysiological role of H. parainfluenzae in SS. Reduced salivary H. parainfluenzae levels in SS patients were confirmed through quantitative PCR. Oral H. parainfluenzae inoculation in NOD mice alleviated focal sialadenitis, improved salivary function, and reduced IFN-γ+CD3+ and IFN-γ+CD8+ T cells in salivary gland-draining lymph nodes, maintaining immune homeostasis against a biased type 1 response. Inoculation also enhanced salivary microbiota diversity, balanced the Firmicutes-to-Proteobacteria ratio, and reduced the overwhelming presence of Pseudomonas mendocina. In vitro, H. parainfluenzae-preconditioned A253 cells limited CD8 T cell expansion with reduced IFN-γ production. These findings suggest that H. parainfluenzae improves oral microbial diversity, promotes homeostatic T-cell immunity, and protects against SS, supporting its potential as a next-generation probiotic.