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<p>Aging weakens neural stem cell (NSC) function and reduces brain plasticity, but this process is shaped by more than the brain alone. Local niche cells become disrupted with age and inflammation, while skeletal muscle sends systemic signals through myokines, metabolites, and vascular interfaces. Evidence from exercise, parabiosis, and rejuvenation studies suggests that preserving muscle health may help protect NSC niches and brain regenerative capacity.</p>

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Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月1日

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  • Weiyi Jiang,
  • Kenon Chua,
  • Hiang Khoon Tan,
  • Eng King Tan,
  • Kun-Yang Lin,
  • Hong-Wen Tang

摘要

Aging weakens neural stem cell (NSC) function and reduces brain plasticity, but this process is shaped by more than the brain alone. Local niche cells become disrupted with age and inflammation, while skeletal muscle sends systemic signals through myokines, metabolites, and vascular interfaces. Evidence from exercise, parabiosis, and rejuvenation studies suggests that preserving muscle health may help protect NSC niches and brain regenerative capacity.