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<p>Oocyte aging is a major cause of age-related fertility decline. This Review summarizes how DNA methylation disruption, aberrant histone modifications, RNA modifications and non-coding RNA dysregulation impair chromatin integrity, meiosis, mitochondrial function and developmental competence. We further discuss epigenetic and metabolism-oriented interventions, including NAD<sup>+</sup> precursors, sirtuin activation and antioxidants, highlighting mechanistic opportunities and translational limitations for improving aged oocyte quality.</p>

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Epigenetics drives oocyte aging: from mechanisms to interventions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月1日

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  • Hui Jia,
  • Jiawei Zhou,
  • Binbin Ma,
  • Mailin Gan,
  • Lei Chen,
  • Xiaofeng Zhou,
  • Linyuan Shen,
  • Li Zhu,
  • Yan Wang

摘要

Oocyte aging is a major cause of age-related fertility decline. This Review summarizes how DNA methylation disruption, aberrant histone modifications, RNA modifications and non-coding RNA dysregulation impair chromatin integrity, meiosis, mitochondrial function and developmental competence. We further discuss epigenetic and metabolism-oriented interventions, including NAD+ precursors, sirtuin activation and antioxidants, highlighting mechanistic opportunities and translational limitations for improving aged oocyte quality.