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<p>Aging is increasingly viewed as an organism-wide process marked by systemic decline and multimorbidity. This Review frames immunosenescence as a context-dependent mediator, amplifier, or consequence of multi-organ dysfunction, integrating niche-centered mechanisms, bidirectional immune–organ interactions, innate–adaptive remodeling, immune–tissue axes, and multidimensional biomarkers. We also highlight current limitations, including context heterogeneity and unresolved causality, and discuss senolytic, senomorphic, and other therapeutic strategies with potential relevance and limitations for healthspan extension.</p><p></p>

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Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月19日

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  • Zhi-Guo Wu,
  • Qiang-Qiang Zhao,
  • Sheng-Rong Lin,
  • Jia-Ying Lei,
  • Cheng-Jun Yang,
  • Shu-Ning Sun,
  • Zhong-Qi Yang,
  • Shi-Hao Ni,
  • Xing-Ling Chen,
  • Lu Lu

摘要

Aging is increasingly viewed as an organism-wide process marked by systemic decline and multimorbidity. This Review frames immunosenescence as a context-dependent mediator, amplifier, or consequence of multi-organ dysfunction, integrating niche-centered mechanisms, bidirectional immune–organ interactions, innate–adaptive remodeling, immune–tissue axes, and multidimensional biomarkers. We also highlight current limitations, including context heterogeneity and unresolved causality, and discuss senolytic, senomorphic, and other therapeutic strategies with potential relevance and limitations for healthspan extension.