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<p>Cellular senescence induced by internal and external stimuli features stable cell cycle arrest and SASP, closely linked to aging and various age-related diseases. It is accompanied by lipid metabolism disorders and epigenetic abnormalities, which interact closely to modulate senescence. This review summarizes their crosstalk in senescence and relevant diseases, aiming to offer new insights and therapeutic targets for alleviating cellular senescence and treating age-related diseases.</p><p></p>

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Crosstalk between lipid metabolism and epigenetics in cellular senescence and age-related diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月20日

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  • Xiao Yu,
  • Fanke Huang,
  • Menghui Hou,
  • Nan Wang,
  • Qianhui Ma,
  • Minghe Li,
  • Chang Zhang,
  • Haiying Zhang,
  • Yingai Shi,
  • Xu He

摘要

Cellular senescence induced by internal and external stimuli features stable cell cycle arrest and SASP, closely linked to aging and various age-related diseases. It is accompanied by lipid metabolism disorders and epigenetic abnormalities, which interact closely to modulate senescence. This review summarizes their crosstalk in senescence and relevant diseases, aiming to offer new insights and therapeutic targets for alleviating cellular senescence and treating age-related diseases.