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<p>.The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing to RPL. This review offers a new paradigm for understanding RPL etiology, with significant clinical value for improving reproductive outcomes.</p>

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Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月19日

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  • Yu Liu,
  • Wenyan Shi,
  • Zhonglin Jiang,
  • Yujie Xu,
  • Meichen Wang,
  • Xiuju Wang,
  • Hongmei Yin,
  • Dong Wang,
  • Feibo Xu,
  • Yuhui Hao,
  • Dongdong Guan,
  • Lei Han

摘要

.The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing to RPL. This review offers a new paradigm for understanding RPL etiology, with significant clinical value for improving reproductive outcomes.