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<p>Emerging evidence shows that inflammaging varies across populations, challenging universal immune-aging models. Urbanization in sub-Saharan Africa—characterized by reduced exposure to infectious diseases and rising rates of noncommunicable diseases—offers a natural experiment for assessing environmental effects on inflammaging. Lower inflammaging in indigenous groups may reflect adaptation to chronic infection, whereas heightened inflammation in industrialized populations suggests ecological imbalance, underscoring the need to include diverse ecological groups in aging research.</p>

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Urbanization, environment, and inflammaging: insights from sub-Saharan Africa

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月13日

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  • Stephen W. Bickler,
  • Matchecane Cossa,
  • Irina Mendes de Sousa,
  • Emília V. Noormahomed

摘要

Emerging evidence shows that inflammaging varies across populations, challenging universal immune-aging models. Urbanization in sub-Saharan Africa—characterized by reduced exposure to infectious diseases and rising rates of noncommunicable diseases—offers a natural experiment for assessing environmental effects on inflammaging. Lower inflammaging in indigenous groups may reflect adaptation to chronic infection, whereas heightened inflammation in industrialized populations suggests ecological imbalance, underscoring the need to include diverse ecological groups in aging research.