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<p>Biological aging and immunosenescence are central to longevity, yet their interplay in centenarians remains unclear. We conducted a cross-sectional study in 160 Colombian centenarians to examine associations between biological age (PhenoAge), immunosenescence and age-related clinical variables. Cytokine profiling (<i>n</i> = 114) and lymphocyte immunophenotyping (<i>n</i> = 42) were assessed. It was observed that better QoL and well-being were significantly associated with lower biological age, while depressive symptoms, prior tobacco use, elevated levels of RANTES and G-CSF as well as a distinct CD8+ T cell phenotype including greater CD27− CD28+ central memory, effector memory, and KLRG1− CD57+ terminally differentiated effector memory T cells (TEMRA), and fewer KLRG1+ CD57+ TEMRA cells were linked to higher biological age. Centenarians were classified into three categories: vigorous (10%), resilient (46.25%), and vulnerable (43.75%). Cytokine levels were similar across the groups. These findings challenge the notion of immunosenescence in centenarians and highlight the value of translational research in geroscience.</p>

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Biological age and immunosenescence in Colombian centenarians

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Juan-Manuel Anaya,
  • Edward A. Ruiz-Narváez,
  • Ivan David Lozada-Martinez,
  • Manuel Rojas,
  • Diana M. Monsalve,
  • Jesús Armando Álvarez-Álvarez,
  • María José Díaz Gutiérrez,
  • Olianis Pájaro,
  • Brenda Guerra,
  • Juan Esteban Gallo,
  • Isaura Torres,
  • Carolina Ramírez-Santana,
  • Andres Angelo Cadena Bonfanti,
  • Yeny Acosta-Ampudia

摘要

Biological aging and immunosenescence are central to longevity, yet their interplay in centenarians remains unclear. We conducted a cross-sectional study in 160 Colombian centenarians to examine associations between biological age (PhenoAge), immunosenescence and age-related clinical variables. Cytokine profiling (n = 114) and lymphocyte immunophenotyping (n = 42) were assessed. It was observed that better QoL and well-being were significantly associated with lower biological age, while depressive symptoms, prior tobacco use, elevated levels of RANTES and G-CSF as well as a distinct CD8+ T cell phenotype including greater CD27− CD28+ central memory, effector memory, and KLRG1− CD57+ terminally differentiated effector memory T cells (TEMRA), and fewer KLRG1+ CD57+ TEMRA cells were linked to higher biological age. Centenarians were classified into three categories: vigorous (10%), resilient (46.25%), and vulnerable (43.75%). Cytokine levels were similar across the groups. These findings challenge the notion of immunosenescence in centenarians and highlight the value of translational research in geroscience.