Scholarlink

<p>Skin aging involves progressive structural and functional decline, yet the underlying molecular mechanisms remain unclear. Here, we report that the antimicrobial peptide S100A7 is markedly reduced in aged keratinocytes and that its depletion leads to transcriptional alterations in differentiation-, autophagy-, and senescence-associated pathways. S100A7 knockdown partially recapitulated senescence-associated signatures, whereas supplementation increased autophagy and attenuated senescence-like phenotypes. These findings support a role for S100A7 as a context-dependent modulator of epidermal homeostasis and establish an AMP–autophagy axis that may contribute to cellular changes during skin aging.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月17日

查看全文
  • Ge Peng,
  • Fumihiro Hattori,
  • Hideoki Ogawa,
  • Ko Okumura,
  • François Niyonsaba

摘要

Skin aging involves progressive structural and functional decline, yet the underlying molecular mechanisms remain unclear. Here, we report that the antimicrobial peptide S100A7 is markedly reduced in aged keratinocytes and that its depletion leads to transcriptional alterations in differentiation-, autophagy-, and senescence-associated pathways. S100A7 knockdown partially recapitulated senescence-associated signatures, whereas supplementation increased autophagy and attenuated senescence-like phenotypes. These findings support a role for S100A7 as a context-dependent modulator of epidermal homeostasis and establish an AMP–autophagy axis that may contribute to cellular changes during skin aging.