Scholarlink

<p>In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (<i>n</i> = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (<i>p</i> = 0.051) and increased from 12mo to 24mo (<i>p</i> = 0.016); GlycAge decreased over the same period (<i>p</i> = 0.027). GlycAge was positively associated with TNF-α (<i>p</i> = 0.030) and ICAM-1 (<i>p</i> = 0.017). Between BL and 24mo, plasma high-branched glycans declined (<i>p</i> = 0.013), bisecting GlcNAcs increased in both plasma (<i>p</i> &lt; 0.001) and IgG (<i>p</i> = 0.01), complement C3 protein (<i>p</i> &lt; 0.001), C3-Man9 (<i>p</i> &lt; 0.001), and C3-Man9Glc1C3 (<i>p</i> = 0.046) were reduced. The absence of a control group warrants cautious interpretation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月1日

查看全文
  • Tea Pribić,
  • Jayanta K. Das,
  • Lovorka Đerek,
  • Daniel W. Belsky,
  • Melissa Orenduff,
  • Kim M. Huffman,
  • William E. Kraus,
  • Helena Deriš,
  • Jelena Šimunović,
  • Tamara Štambuk,
  • Azra Frkatović-Hodžić,
  • Virginia B. Kraus,
  • Sai Krupa Das,
  • Susan B. Racette,
  • Nirad Banskota,
  • Luigi Ferrucci,
  • Carl Pieper,
  • Nathan E. Lewis,
  • Gordan Lauc,
  • Sridevi Krishnan

摘要

In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.