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<p>Accurate classification of neurodegenerative disorders remains a challenge in neuroscience. Using open-source electroencephalography (EEG) data, we investigated electrophysiological signatures to differentiate frontotemporal dementia (FTD) from Alzheimer’s disease (AD) via complexity measures. Traditional relative band power analysis showed consistent increases in lower-frequency activity but did not distinguish the two disorders after correction. In contrast, fractal dimension and long-range temporal correlations (LRTCs) revealed distinct topographical differences: AD exhibited rostral dominance in fractal dimension, whereas FTD showed caudal dominance. Both disorders demonstrated reduced LRTCs, particularly in caudal regions, indicating disrupted large-scale neural dynamics. These findings suggest that complexity-based EEG features may offer a reliable, cost-effective tool for distinguishing neurodegenerative conditions, complementing traditional neuroimaging approaches.</p>

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Evaluating EEG complexity and spectral signatures in Alzheimer’s disease and frontotemporal dementia: evidence for rostrocaudal asymmetry

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月9日

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  • Kassra Ghassemkhani,
  • Kevin S. Saroka,
  • Blake T. Dotta

摘要

Accurate classification of neurodegenerative disorders remains a challenge in neuroscience. Using open-source electroencephalography (EEG) data, we investigated electrophysiological signatures to differentiate frontotemporal dementia (FTD) from Alzheimer’s disease (AD) via complexity measures. Traditional relative band power analysis showed consistent increases in lower-frequency activity but did not distinguish the two disorders after correction. In contrast, fractal dimension and long-range temporal correlations (LRTCs) revealed distinct topographical differences: AD exhibited rostral dominance in fractal dimension, whereas FTD showed caudal dominance. Both disorders demonstrated reduced LRTCs, particularly in caudal regions, indicating disrupted large-scale neural dynamics. These findings suggest that complexity-based EEG features may offer a reliable, cost-effective tool for distinguishing neurodegenerative conditions, complementing traditional neuroimaging approaches.