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<p>We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (<i>n</i> = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.</p>

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Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Kavita M. Dhodapkar,
  • Sharon Castellino,
  • Shivani Kapadia,
  • Maryam I. Azeem,
  • Ava Horvat,
  • Taylor Lawrence,
  • Deborah DeRyckere,
  • Madhav V. Dhodapkar

摘要

We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.