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<p>Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregulation of amino acids and energy metabolism in both pre-frail and frail participants. Remarkably, upregulated betaine levels emerged as a specific biochemical signature of pre-frail females, holding promise for the development of novel targeted interventions.</p>

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1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月12日

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  • Carmen Marino,
  • Alberto Imarisio,
  • Clara Gasparri,
  • Enza Napolitano,
  • Anna Di Maio,
  • Micol Avenali,
  • Gabriele Buongarzone,
  • Caterina Galandra,
  • Marta Picascia,
  • Manuela Grimaldi,
  • Francesco Errico,
  • Mariangela Rondanelli,
  • Anna Maria D’Ursi,
  • Enza Maria Valente,
  • Alessandro Usiello

摘要

Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregulation of amino acids and energy metabolism in both pre-frail and frail participants. Remarkably, upregulated betaine levels emerged as a specific biochemical signature of pre-frail females, holding promise for the development of novel targeted interventions.