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<p>Bacteria-derived lipopeptides are immunogenic triggers of host defences in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate induced systemic resistance against microbial infection in various plant species. Whether and how these molecules are perceived at the plant cell surface remains elusive. Here we reveal that immune activation in <i>Arabidopsis thaliana</i> by the lipopeptide elicitor surfactin is mediated via a specific interaction with membrane sphingolipids. It relies on host membrane remodelling and subsequent activation of mechanosensitive ion channels. This mechanism leads to host defence potentiation and resistance to the necrotrophic fungus <i>Botrytis cinerea</i> and appears distinct from pattern-triggered immunity induced by classical host pattern recognition receptors. These results reveal a previously uncharacterized mechanism through which lipopeptides derived from non-pathogenic bacteria activate plant immune responses.</p>

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Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月20日

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  • Guillaume Gilliard,
  • Jelena Pršić,
  • Jean-Marc Crowet,
  • Catherine Chemotti,
  • Jahed Ahmed,
  • Joseph Lorent,
  • Marie-Dominique Jolivet,
  • Sabrina Egli,
  • Stéphane Egée,
  • Guillaume Bouyer,
  • Gaëlle Race,
  • Lennard van Buren,
  • Anke Van Den Berghe,
  • Anthony Argüelles-Arias,
  • Marion Mathelié-Guinlet,
  • Heba Ibrahim,
  • Manon Genva,
  • Laetitia Fouillen,
  • Cécile Mirande-Bret,
  • Oihana Razin,
  • Brian Vue,
  • Milan Župunski,
  • W. Patricio Luzuriaga-Loaiza,
  • Estelle Deboever,
  • M. Nail Nasir,
  • Laurence Lins,
  • Patrick Van Der Smissen,
  • Farah Boubsi,
  • Sabine Eschrig,
  • Véronique Germain,
  • Monica Höfte,
  • Cyril Zipfel,
  • Yves F. Dufrêne,
  • Donatienne Tyteca,
  • Alexandros Koutsioubas,
  • Paola Brocca,
  • Guido Grossmann,
  • Stefanie Ranf,
  • Stephan Dorey,
  • Barbara De Coninck,
  • Thorsten Nürnberger,
  • Sébastien Mongrand,
  • Julien Gronnier,
  • Valeria Rondelli,
  • Magali Deleu,
  • Marc Ongena

摘要

Bacteria-derived lipopeptides are immunogenic triggers of host defences in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate induced systemic resistance against microbial infection in various plant species. Whether and how these molecules are perceived at the plant cell surface remains elusive. Here we reveal that immune activation in Arabidopsis thaliana by the lipopeptide elicitor surfactin is mediated via a specific interaction with membrane sphingolipids. It relies on host membrane remodelling and subsequent activation of mechanosensitive ion channels. This mechanism leads to host defence potentiation and resistance to the necrotrophic fungus Botrytis cinerea and appears distinct from pattern-triggered immunity induced by classical host pattern recognition receptors. These results reveal a previously uncharacterized mechanism through which lipopeptides derived from non-pathogenic bacteria activate plant immune responses.