Scholarlink

<p>Global warming poses a substantial threat to crop productivity, yet the genetic basis of thermotolerance in wheat remains poorly understood. Here we cloned a heat stress tolerance (HST) gene, Ta<i>HST2</i>, and revealed that it underwent functional silencing during wheat domestication. As a negative regulator of basal HST, Ta<i>HST2</i> was progressively suppressed through intronic sequence polymorphisms and epigenetic modifications, which might be an evolutionary consequence of hexaploidization. Haplotype analysis suggests strong artificial selection against Ta<i>HST2</i> expression, favouring improved thermotolerance in cultivated wheat. Further studies demonstrated that Ta<i>HST2</i> encodes a ubiquitin hydrolase that stabilizes HST repression proteins <i>Ta</i>HSC701 and <i>Ta</i>HSC702, thereby modulating heat response pathways. Our findings uncover a potential key genetic event in wheat evolution and offer new strategies for utilizing synthetic hexaploidy and octoploid wheat to breed heat-resilient varieties.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

TaHST2 silencing shapes basal heat tolerance in allohexaploid wheat

  • 期刊论文

  • 发表日期：

    2026年3月20日

查看全文
  • Runqi Zhang,
  • Guoyu Liu,
  • Shanshan Zhai,
  • Xinhao Meng,
  • Jiazheng Yu,
  • Yuqi Zhang,
  • Shidian Wen,
  • Xinghua Luo,
  • Wenxuan Han,
  • Hongyao Lou,
  • Tianjiao Shao,
  • Rongqi Liang,
  • Jun Ma,
  • Huijie Zhai,
  • Mingshan You,
  • Chaojie Xie,
  • Yufeng Zhang,
  • Jie Liu,
  • Zhaorong Hu,
  • Weilong Guo,
  • Qixin Sun,
  • Jiewen Xing,
  • Zhongfu Ni,
  • Baoyun Li

摘要

Global warming poses a substantial threat to crop productivity, yet the genetic basis of thermotolerance in wheat remains poorly understood. Here we cloned a heat stress tolerance (HST) gene, TaHST2, and revealed that it underwent functional silencing during wheat domestication. As a negative regulator of basal HST, TaHST2 was progressively suppressed through intronic sequence polymorphisms and epigenetic modifications, which might be an evolutionary consequence of hexaploidization. Haplotype analysis suggests strong artificial selection against TaHST2 expression, favouring improved thermotolerance in cultivated wheat. Further studies demonstrated that TaHST2 encodes a ubiquitin hydrolase that stabilizes HST repression proteins TaHSC701 and TaHSC702, thereby modulating heat response pathways. Our findings uncover a potential key genetic event in wheat evolution and offer new strategies for utilizing synthetic hexaploidy and octoploid wheat to breed heat-resilient varieties.