The emerging epitranscriptomic modification ac4C regulates plant development and stress adaptation
摘要
N4-acetylcytidine is an evolutionarily conserved RNA modification that plays a key role in regulating transcript stability and translation. Although extensively studied in mammals, its prevalence and functional importance in plant transcriptomes remain unclear. Recent advances in transcriptome-wide mapping and functional characterization have revealed the important role of N4-acetylcytidine modification in plant-specific processes. Here we discuss how N4-acetylcytidine is deposited by plant writers, summarize its influence on plant development and adaptation, outline the major challenges and future directions in the field and highlight its potential applications for crop improvement.