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<p>Meiotic recombination, via the formation of crossovers (COs), re-assorts parental alleles and dictate which traits are inherited together, or not. The recombination rate is not homogeneous across the genome, and uncovering the causes of these fluctuations can inform our understanding of recombination and genome evolution. In this study we show that presence of sequence divergence (polymorphism) between homologous chromosomes can dictate where crossovers are formed in <i>Arabidopsis thaliana</i>. Indeed, presence of polymorphism increases the local recombination rate, turning cold regions of the genome hot. This relocation occurs at the expense of non-polymorphic regions, which become colder. This global overhaul of the CO landscape is dependent on the mismatch repair (MMR) machinery. Our data suggests that MMR has a pro-CO role, driving COs to regions of the genome where it could detect sequence differences between homologous chromosomes. Our study demonstrates that polymorphism can be a major recombination driver in <i>A. thaliana</i>.</p>

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Polymorphism can extensively reshape the genome-wide crossover landscape in Arabidopsis thaliana

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月1日

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  • Benoît Madec,
  • Maëla Sémery,
  • Qichao Lian,
  • Mohamad Yassine,
  • Loïse Léonard-Moniot,
  • Éric Espagne,
  • Sophie Piquerez,
  • Chloé Girard

摘要

Meiotic recombination, via the formation of crossovers (COs), re-assorts parental alleles and dictate which traits are inherited together, or not. The recombination rate is not homogeneous across the genome, and uncovering the causes of these fluctuations can inform our understanding of recombination and genome evolution. In this study we show that presence of sequence divergence (polymorphism) between homologous chromosomes can dictate where crossovers are formed in Arabidopsis thaliana. Indeed, presence of polymorphism increases the local recombination rate, turning cold regions of the genome hot. This relocation occurs at the expense of non-polymorphic regions, which become colder. This global overhaul of the CO landscape is dependent on the mismatch repair (MMR) machinery. Our data suggests that MMR has a pro-CO role, driving COs to regions of the genome where it could detect sequence differences between homologous chromosomes. Our study demonstrates that polymorphism can be a major recombination driver in A. thaliana.