Scholarlink

<p>Targeted lung delivery of therapeutics is critical for various respiratory diseases. However, the rational design of lung-targeting nanocarriers through fine-tuning of polymeric structures remains challenging. Herein, we reported the development of lung-targeting, heteropolypeptide-grafted nanoparticles (NPs), whose targeting ability was dependent on the copolymer sequence that mediated in situ erythrocyte hitchhiking. Specifically, the incorporation of β-branched amino acid residues in poly(<sub>L</sub>-glutamic acid)s, like valine and isoleucine, resulted in gradient copolymer sequence with terminal hydrophobic segments. The corresponding heteropolypeptide-decorated NPs with hydrophobic coronas thus showed high affinity to red blood cell membranes, leading to accumulation in lung tissues at up to 37% of the&#xa0;injected dose through erythrocyte hitchhiking. This strategy mediated effective lung-targeting of CeO<sub>2</sub>, showing anti-oxidant effect that alleviated pulmonary inflammation to treat acute lung injury. This work highlights the importance of copolymer sequence in tuning the biodistribution of polymer-decorated NPs, shedding light on the design of nanocarriers for pulmonary delivery.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sequence-regulated, lung-targeting heteropolypeptide nanoparticles via in situ erythrocyte hitchhiking

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月30日

查看全文
  • Ning Li,
  • Jiahe Shen,
  • Yuheng Lei,
  • Junhong Wang,
  • Wei Zhou,
  • Aoting Li,
  • Hui Liu,
  • Shanshan Xiao,
  • Jing Zhao,
  • Shaobo Feng,
  • Guanglin Wang,
  • Lichen Yin,
  • Ziyuan Song

摘要

Targeted lung delivery of therapeutics is critical for various respiratory diseases. However, the rational design of lung-targeting nanocarriers through fine-tuning of polymeric structures remains challenging. Herein, we reported the development of lung-targeting, heteropolypeptide-grafted nanoparticles (NPs), whose targeting ability was dependent on the copolymer sequence that mediated in situ erythrocyte hitchhiking. Specifically, the incorporation of β-branched amino acid residues in poly(L-glutamic acid)s, like valine and isoleucine, resulted in gradient copolymer sequence with terminal hydrophobic segments. The corresponding heteropolypeptide-decorated NPs with hydrophobic coronas thus showed high affinity to red blood cell membranes, leading to accumulation in lung tissues at up to 37% of the injected dose through erythrocyte hitchhiking. This strategy mediated effective lung-targeting of CeO2, showing anti-oxidant effect that alleviated pulmonary inflammation to treat acute lung injury. This work highlights the importance of copolymer sequence in tuning the biodistribution of polymer-decorated NPs, shedding light on the design of nanocarriers for pulmonary delivery.