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<p>Human adipose tissues are solid organs distributed throughout the body in specific locations and are thought to have dichotomous functions: white adipose tissue stores triglycerides as an energy reservoir, and brown adipose tissue uses metabolic fuels to generate heat. To define the transcriptional profile of six principal adipose depots, we analyze tissue from 11 autopsies (3 F/8 M, 16-71 y) of patients who had different underlying diseases. Despite global similarities in terms of cell type proportions, each depot has a distinct transcriptomic signature and functional profile. Each human’s adipose tissues are more similar to each other than to the anatomically and functionally matching depots in other patients. The transcriptomic pattern of subcutaneous white adipose tissue can even be used to predict the human donor. This pattern suggests that individualized factors such as genetics, age, environment, diet, and disease play impactful roles in coordinating the behavior of the whole-body adipose tissue depot.</p>

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Transcriptomic profiling of human brown and white adipose tissue depots

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月29日

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  • Nhuquynh Nguyen,
  • Cheryl Cero,
  • Adrienne R. Guarnieri,
  • Ju Hee Kim,
  • Kelly T. Long,
  • Jurgen Heymann,
  • Sahara L. Ali,
  • Emily V. Leary,
  • Aaron M. Cypess

摘要

Human adipose tissues are solid organs distributed throughout the body in specific locations and are thought to have dichotomous functions: white adipose tissue stores triglycerides as an energy reservoir, and brown adipose tissue uses metabolic fuels to generate heat. To define the transcriptional profile of six principal adipose depots, we analyze tissue from 11 autopsies (3 F/8 M, 16-71 y) of patients who had different underlying diseases. Despite global similarities in terms of cell type proportions, each depot has a distinct transcriptomic signature and functional profile. Each human’s adipose tissues are more similar to each other than to the anatomically and functionally matching depots in other patients. The transcriptomic pattern of subcutaneous white adipose tissue can even be used to predict the human donor. This pattern suggests that individualized factors such as genetics, age, environment, diet, and disease play impactful roles in coordinating the behavior of the whole-body adipose tissue depot.