Scholarlink

<p>The stereospecific conversion of alkanols plays a pivotal role in synthetic chemistry and drug discovery. Among the substantial advances, the Mitsunobu reaction has long stood out as a powerful platform for C(sp<sup>3</sup>)-O bond activation to achieve the transformation of alkanols. Due to the inherent environmental drawbacks of phosphorus chemistry, an alternative element is pressingly demanded. Herein, we develop well-designed sulfoxide catalysts for an alternative catalytic Mitsunobu-type reaction with broad substrate scope, generating H<sub>2</sub>O as the sole by-product. Kinetic studies, mechanistic investigations, and density functional theory (DFT) calculations provide comprehensive mechanistic insights and uncover key structure-reactivity relationships. This approach establishes a sustainable and atom-economical pathway for the Mitsunobu-type reaction, and expands the conceptual scope of sulfur catalysis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Reforging Mitsunobu reaction via sulfoxides-catalyzed C(sp3)-O bond activation of alkanols

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

查看全文
  • Qigang Li,
  • Wannan Zhang,
  • Jiaxin Liu,
  • Jun Yang

摘要

The stereospecific conversion of alkanols plays a pivotal role in synthetic chemistry and drug discovery. Among the substantial advances, the Mitsunobu reaction has long stood out as a powerful platform for C(sp3)-O bond activation to achieve the transformation of alkanols. Due to the inherent environmental drawbacks of phosphorus chemistry, an alternative element is pressingly demanded. Herein, we develop well-designed sulfoxide catalysts for an alternative catalytic Mitsunobu-type reaction with broad substrate scope, generating H2O as the sole by-product. Kinetic studies, mechanistic investigations, and density functional theory (DFT) calculations provide comprehensive mechanistic insights and uncover key structure-reactivity relationships. This approach establishes a sustainable and atom-economical pathway for the Mitsunobu-type reaction, and expands the conceptual scope of sulfur catalysis.