Scholarlink

<p>The dorsal raphe nucleus (DRN) shapes behaviors including mood and motivation. The DRN contains molecularly distinct and topographically organized neurons that target specific forebrain regions. To understand how DRN neurons process sensory information, we investigated the spatiotemporal activity patterns of DRN neurons, DRN axons, and their forebrain targets in zebrafish. We found a remarkable topographic organization of ongoing activity and sensory-motor responses within the DRN. A subset of DRN neurons was driven by locomotion and sensory stimuli. Gad1-positive DRN neurons exhibited distinct activity during rest and sensory-motor stimulation. DRN axons in the forebrain showed topographically organized excitation and inhibition in response to sensory stimulation and locomotion. DRN axons covaried with forebrain neuronal activity. DRN ablation reduced the synchrony and sensory-motor responses of forebrain neurons and enhanced defensive behaviors. We revealed the functional diversity of DRN neurons and their role in transmitting sensory and locomotor signals via topographically organized forebrain projections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月16日

查看全文
  • Aytac Kadir Mutlu,
  • Bram Serneels,
  • Christoph Wiest,
  • Anh-Tuan Trinh,
  • Ricarda Bardenhewer,
  • Fabrizio Palumbo,
  • Oda Bjørnevik Frisvold,
  • Inger Kristine Fjeldskaar Aukrust,
  • Anna Maria Ostenrath,
  • Emre Yaksi

摘要

The dorsal raphe nucleus (DRN) shapes behaviors including mood and motivation. The DRN contains molecularly distinct and topographically organized neurons that target specific forebrain regions. To understand how DRN neurons process sensory information, we investigated the spatiotemporal activity patterns of DRN neurons, DRN axons, and their forebrain targets in zebrafish. We found a remarkable topographic organization of ongoing activity and sensory-motor responses within the DRN. A subset of DRN neurons was driven by locomotion and sensory stimuli. Gad1-positive DRN neurons exhibited distinct activity during rest and sensory-motor stimulation. DRN axons in the forebrain showed topographically organized excitation and inhibition in response to sensory stimulation and locomotion. DRN axons covaried with forebrain neuronal activity. DRN ablation reduced the synchrony and sensory-motor responses of forebrain neurons and enhanced defensive behaviors. We revealed the functional diversity of DRN neurons and their role in transmitting sensory and locomotor signals via topographically organized forebrain projections.