Scholarlink

<p>The development of a green, sustainable, and environment-friendly activation model is of great significance in catalytic chemistry. Herein, a transition-metal- and ligand-free, base-catalyzed regioselective C(sp<sup>3</sup>)–Si bond activation of silacyclobutanes (SCBs) and benzosilacyclobutenes (BSBs) has been developed. The protocol features a simple catalytic system that proceeds smoothly under air atmosphere without requiring inert gas protection. A variety of SCBs and BSBs are competent substrates, along with a range of nucleophiles as coupling partners. Furthermore, the strategy provides a straightforward platform for the late-stage functionalization of various bioactive molecules, enabling access to diverse quaternary silicon-containing scaffolds. Preliminary mechanistic investigations indicate that the C–Si bond cleavage is involved in the rate-determining step, and the hydrogen source originates from the nucleophile. In addition, the proposed mechanism is consistent with our experimental results and further supported by DFT calculations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Base-catalyzed regioselective C(sp3)–Si bond activation of silacyclobutanes and benzosilacyclobutenes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月16日

查看全文
  • Yuanfang Kong,
  • Delong Mu

摘要

The development of a green, sustainable, and environment-friendly activation model is of great significance in catalytic chemistry. Herein, a transition-metal- and ligand-free, base-catalyzed regioselective C(sp3)–Si bond activation of silacyclobutanes (SCBs) and benzosilacyclobutenes (BSBs) has been developed. The protocol features a simple catalytic system that proceeds smoothly under air atmosphere without requiring inert gas protection. A variety of SCBs and BSBs are competent substrates, along with a range of nucleophiles as coupling partners. Furthermore, the strategy provides a straightforward platform for the late-stage functionalization of various bioactive molecules, enabling access to diverse quaternary silicon-containing scaffolds. Preliminary mechanistic investigations indicate that the C–Si bond cleavage is involved in the rate-determining step, and the hydrogen source originates from the nucleophile. In addition, the proposed mechanism is consistent with our experimental results and further supported by DFT calculations.