Scholarlink

<p>Anion-π<sup>+</sup> phototheranostic agents (PTAs) have attracted considerable interest for their exceptional luminescence and reactive oxygen species (ROS). However, current development is constrained by limited structural diversity and lack of second near-infrared (NIR-II) emission and photothermal performance, with the role of organic π-conjugated anions remaining unexplored. Here, we propose an organic π-conjugated anion-exchange strategy to construct advanced NIR-II PTAs. DTPAP-2B (with Br<sup>-</sup>) and DTPAP-2P (with pentacyanocyclopentadiene anion ((CCN)<sub>5</sub><sup>-</sup>)), were synthesized. Upon nanoformulation, DTPAP-2P NPs exhibit pronounced absorption redshift, intense NIR-II emission, a large Stokes shift (340 nm), superior ROS generation, and high photothermal conversion efficiency (72%) compared to DTPAP-2B NPs. Single-crystal and theoretical analyses reveal that the planar (CCN)<sub>5</sub><sup>-</sup> anion enhances dual anion-π<sup>+</sup> interactions, promoting intramolecular charge transfer while suppressing intermolecular π-π stacking. This enables high-resolution NIR-II angiography and effective NIR-II imaging-guided synergistic photodynamic/photothermal therapy in female mice model. This work establishes organic π-conjugated anion exchange as a powerful strategy for developing robust NIR-II PTAs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Organic planar π-conjugated anions enable structural design of anion-π+ NIR-II phototheranostic agents

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月8日

查看全文
  • Ying Zhang,
  • Mingyang Han,
  • Guoyu Jiang,
  • Lingxiu Liu,
  • Chunbin Li,
  • Lina Feng,
  • Jianye Gong,
  • Jianguo Wang,
  • Ben Zhong Tang

摘要

Anion-π+ phototheranostic agents (PTAs) have attracted considerable interest for their exceptional luminescence and reactive oxygen species (ROS). However, current development is constrained by limited structural diversity and lack of second near-infrared (NIR-II) emission and photothermal performance, with the role of organic π-conjugated anions remaining unexplored. Here, we propose an organic π-conjugated anion-exchange strategy to construct advanced NIR-II PTAs. DTPAP-2B (with Br-) and DTPAP-2P (with pentacyanocyclopentadiene anion ((CCN)5-)), were synthesized. Upon nanoformulation, DTPAP-2P NPs exhibit pronounced absorption redshift, intense NIR-II emission, a large Stokes shift (340 nm), superior ROS generation, and high photothermal conversion efficiency (72%) compared to DTPAP-2B NPs. Single-crystal and theoretical analyses reveal that the planar (CCN)5- anion enhances dual anion-π+ interactions, promoting intramolecular charge transfer while suppressing intermolecular π-π stacking. This enables high-resolution NIR-II angiography and effective NIR-II imaging-guided synergistic photodynamic/photothermal therapy in female mice model. This work establishes organic π-conjugated anion exchange as a powerful strategy for developing robust NIR-II PTAs.