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<p>Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the base-pairing ambiguity. We validate ZAT-DNA for secure key storage, demonstrating error-free encoding, storage, and high-fidelity nanopore retrieval of 32-bit and 64-bit cryptographic keys. ZAT-DNA blocks polymerase-based copying and protects non-fungible tokens by preventing functional duplication. For larger datasets, we present a hybrid “Babel-DNA” architecture: multiple encrypted images are co-encoded in a single regular DNA pool, with each selectively decryptable only via its cognate, non-replicable ZAT-DNA key. This provides a practical framework for molecular access control, secure DNA-encoded databases, and scarce molecular tokens.</p>

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ZAT-DNA enables DNA data storage with molecular-layer non-replicability

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月8日

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  • Lifu Song,
  • Gaoli Wang,
  • Yifeng Wei,
  • Yingjie Huang,
  • Yunkun Zhang,
  • Xuesong Liu,
  • Zhiguang Yuchi,
  • Yingjin Yuan,
  • Yunzi Luo,
  • Yan Zhang

摘要

Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the base-pairing ambiguity. We validate ZAT-DNA for secure key storage, demonstrating error-free encoding, storage, and high-fidelity nanopore retrieval of 32-bit and 64-bit cryptographic keys. ZAT-DNA blocks polymerase-based copying and protects non-fungible tokens by preventing functional duplication. For larger datasets, we present a hybrid “Babel-DNA” architecture: multiple encrypted images are co-encoded in a single regular DNA pool, with each selectively decryptable only via its cognate, non-replicable ZAT-DNA key. This provides a practical framework for molecular access control, secure DNA-encoded databases, and scarce molecular tokens.