Scholarlink

<p>Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrotic remodeling of the skin and internal organs. Fibrotic tissue changes are considered hardly reversible with current therapies, suggesting that new strategies are required to modulate the disease-associated molecular and cellular phenotype to enable regeneration of affected tissues. Here, analyzing skin biopsy samples from patients with SSc who had received CD19-CAR T cell therapy as part of the CASTLE study or named patient use, we demonstrate structural regeneration of SSc skin structure, as evidenced by recovery of skin papillae. Consistent with these histological changes, cyclic in situ hybridization and imaging mass cytometry analyses suggested that fibroblast populations shifted towards a physiological state, both in terms of composition and function. Moreover, we describe signs of vascular repair and changes in epidermal cell function. These results suggest that B cell depletion using CD19-CAR T cell therapy may lead to skin tissue remodeling in SSc and highlight its potential for tissue regeneration in fibrotic diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月23日

查看全文
  • Aleix Rius Rigau,
  • Meilin Xu,
  • Ziyuan Liu,
  • Sara Chenguiti Fakhouri,
  • Janina Auth,
  • Panagiotis Garantziotis,
  • Andrea Zoli,
  • Manoj Kumar Selvaraju,
  • Maria Gabriella Raimondo,
  • Carlo Tur,
  • Tim Filla,
  • Paula Gehringer,
  • Markus Eckstein,
  • Fabian Müller,
  • Armin Atzinger,
  • Moritz Ronicke,
  • Arif Ekici,
  • Rafael Schmid,
  • Andreas Wirsching,
  • Melanie Hagen,
  • Sebastian Böltz,
  • Tobias Krickau,
  • Raymund E. Horch,
  • Carola Berking,
  • Ricardo Grieshaber-Bouyer,
  • Andreas Ramming,
  • Pooja Gupta,
  • Aline Bozec,
  • Andreas Mackensen,
  • Jörg HW Distler,
  • Georg Schett,
  • Yi-Nan Li,
  • Christina Bergmann

摘要

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrotic remodeling of the skin and internal organs. Fibrotic tissue changes are considered hardly reversible with current therapies, suggesting that new strategies are required to modulate the disease-associated molecular and cellular phenotype to enable regeneration of affected tissues. Here, analyzing skin biopsy samples from patients with SSc who had received CD19-CAR T cell therapy as part of the CASTLE study or named patient use, we demonstrate structural regeneration of SSc skin structure, as evidenced by recovery of skin papillae. Consistent with these histological changes, cyclic in situ hybridization and imaging mass cytometry analyses suggested that fibroblast populations shifted towards a physiological state, both in terms of composition and function. Moreover, we describe signs of vascular repair and changes in epidermal cell function. These results suggest that B cell depletion using CD19-CAR T cell therapy may lead to skin tissue remodeling in SSc and highlight its potential for tissue regeneration in fibrotic diseases.