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<p>The molecular characterization of chicken cells provides insight into avian physiology and vertebrate evolution. Here we present a single-cell RNA-sequencing (scRNA-seq) atlas of the chicken, encompassing 1.57 million cells across 157 cell types from 36 tissues from 16 chickens, as well as spatial transcriptomes from 1 chicken embryo. We further acquire scRNA-seq data from 3 turtles (230 thousand cells, 14 tissues) and 2 ducks (22 thousand cells, 3 tissues), and integrated our data with publicly available human scRNA-seq data (960 thousand cells, 32 tissues) to explore their evolutionary conservation, particularly of immune cells. In chicken, follicular dendritic cells, unlike in mammals, exhibit myeloid rather than stromal origins and help promote B cell proliferation and migration in the bursa of Fabricius. γδ T cell subsets vary across species, reflecting the evolution of pathogen recognition and signaling mechanisms among amniotes. Our transcriptomics data thus provide a resource to study chicken cell biology and amniote evolution, highlighting immune cell similarities and distinctions arising from evolutionary divergence.</p>

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Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月5日

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  • Fei Wang,
  • Jilong Ren,
  • Yaqi Zhou,
  • Wuqiang Huo,
  • Huichao Liu,
  • Mumu Qin,
  • Yi Jing,
  • Zhongtao Yin,
  • Tao Shi,
  • Huiquan Shan,
  • Guanghui Tan,
  • Haoping Wang,
  • Xi Guo,
  • Junpu Mei,
  • Zhen Yue,
  • Zhuocheng Hou,
  • Huaijun Zhou,
  • Jiuzhou Song,
  • Søren Egedal Degn,
  • Lin Lin,
  • Yonglun Luo,
  • Feilong Meng,
  • Xiaodong Fang,
  • Haihan Zhang,
  • Xi He,
  • Lingzhao Fang,
  • Yu Jiang

摘要

The molecular characterization of chicken cells provides insight into avian physiology and vertebrate evolution. Here we present a single-cell RNA-sequencing (scRNA-seq) atlas of the chicken, encompassing 1.57 million cells across 157 cell types from 36 tissues from 16 chickens, as well as spatial transcriptomes from 1 chicken embryo. We further acquire scRNA-seq data from 3 turtles (230 thousand cells, 14 tissues) and 2 ducks (22 thousand cells, 3 tissues), and integrated our data with publicly available human scRNA-seq data (960 thousand cells, 32 tissues) to explore their evolutionary conservation, particularly of immune cells. In chicken, follicular dendritic cells, unlike in mammals, exhibit myeloid rather than stromal origins and help promote B cell proliferation and migration in the bursa of Fabricius. γδ T cell subsets vary across species, reflecting the evolution of pathogen recognition and signaling mechanisms among amniotes. Our transcriptomics data thus provide a resource to study chicken cell biology and amniote evolution, highlighting immune cell similarities and distinctions arising from evolutionary divergence.