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<p>We report the experimental super-resolution of pairs of point-like fluorescent sources using a modified image inversion interferometer microscope. The technique is inspired by recent developments in the application of quantum parameter estimation theory to semiclassical imaging problems. We find that the image inversion technique requires special polarization filtering to account for the dipolar nature of the emission. Using an azimuthal polarizer, we obtain improvements in the Fisher information of source separation by over an order of magnitude relative to direct imaging. Unlike established super-resolution fluorescence techniques, the method does not require sequential photoswitching/blinking of the fluorophores, and thus could facilitate significant speed-ups for certain biological imaging/tracking tasks.</p>

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Quantum-inspired super-resolution of fluorescent point-like sources

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月6日

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  • Cheyenne S. Mitchell,
  • Dhananjay Dhruva,
  • Zachary P. Burke,
  • David J. Durden,
  • Armine I. Dingilian,
  • Mikael P. Backlund

摘要

We report the experimental super-resolution of pairs of point-like fluorescent sources using a modified image inversion interferometer microscope. The technique is inspired by recent developments in the application of quantum parameter estimation theory to semiclassical imaging problems. We find that the image inversion technique requires special polarization filtering to account for the dipolar nature of the emission. Using an azimuthal polarizer, we obtain improvements in the Fisher information of source separation by over an order of magnitude relative to direct imaging. Unlike established super-resolution fluorescence techniques, the method does not require sequential photoswitching/blinking of the fluorophores, and thus could facilitate significant speed-ups for certain biological imaging/tracking tasks.