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<p>Topical treatment remains the standard for radiation-induced dermatitis, which affects approximately 95% of radiotherapy patients. However, the robust skin barrier significantly restricts transdermal drug permeability, compromising therapeutic efficacy. Here we show a NIR-Ⅱ light and endogenous H<sub>2</sub>O<sub>2</sub> dual-propelled Janus nanomotor (Au-hSiO<sub>2</sub>-Pt-TA), which enhances skin permeability by a factor of 12.8 compared with passive nanoparticles. By leveraging the synergistic advantages of self-thermophoresis and self-electrophoresis, these motors enable non-invasive, deep penetration through directional movement. Intriguingly, we find that NIR-II-induced hyperthermia (~ 45 °C) triggers neuro-immune regulation via the CGRP-RAMP1 axis, which suppresses inflammatory cell recruitment and migration while polarizing macrophages toward a pro-repair phenotype, thereby alleviating radiation-induced systemic inflammatory responses. Additionally, tannic acid loaded on the nanomotors functions as an efficient ROS scavenger, further mitigating radiation-induced oxidative stress. Overall, the movable nanomotors offer a potent strategy for RD and demonstrate high efficacy through combined neuro-immunoregulation and ROS scavenging.</p>

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Janus nanomotors for topical treatment of radiation-induced dermatitis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月4日

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  • Wen Zhang,
  • Wei Liu,
  • Xiaoyu Zhao,
  • Yuanfang Chen,
  • Changfen Bi,
  • Shuqin Li,
  • Bingwen Zou,
  • Luntao Liu,
  • Saijun Fan

摘要

Topical treatment remains the standard for radiation-induced dermatitis, which affects approximately 95% of radiotherapy patients. However, the robust skin barrier significantly restricts transdermal drug permeability, compromising therapeutic efficacy. Here we show a NIR-Ⅱ light and endogenous H2O2 dual-propelled Janus nanomotor (Au-hSiO2-Pt-TA), which enhances skin permeability by a factor of 12.8 compared with passive nanoparticles. By leveraging the synergistic advantages of self-thermophoresis and self-electrophoresis, these motors enable non-invasive, deep penetration through directional movement. Intriguingly, we find that NIR-II-induced hyperthermia (~ 45 °C) triggers neuro-immune regulation via the CGRP-RAMP1 axis, which suppresses inflammatory cell recruitment and migration while polarizing macrophages toward a pro-repair phenotype, thereby alleviating radiation-induced systemic inflammatory responses. Additionally, tannic acid loaded on the nanomotors functions as an efficient ROS scavenger, further mitigating radiation-induced oxidative stress. Overall, the movable nanomotors offer a potent strategy for RD and demonstrate high efficacy through combined neuro-immunoregulation and ROS scavenging.