Scholarlink

<p>Mucosal homeostasis after birth depends on coordinated interactions between the microbiota and the immune system, with barrier tissues employing distinct mechanisms. Here, we show that maternal Immunoglobulin G (IgG), transferred both in utero and via breastfeeding, reaches the murine neonatal salivary glands and is secreted into saliva, where it recognizes maternal oral microbes and regulates colonization. Offspring lacking in utero-derived IgG show heightened salivary T- and B-cell activation, followed by alterations in the IgG/IgA balance in adult saliva. While postnatal microbiota is essential for priming salivary adaptive immunity, perinatal IgG intrinsically restrains the adaptive responses independent of microbial load. In utero-derived IgG further shapes adult gingival immunity and limits destructive inflammation in murine periodontitis. By contrast, breast milk antibodies promote timely and proper epithelial maturation, a process dependent on microbial load. Thus, we uncover distinct yet complementary roles of pre- and postnatal maternal antibodies in governing oral immune development and long-term protection against oral disease.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Maternal antibodies regulate the establishment of murine oral and salivary mucosal immunity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月10日

查看全文
  • Reem Naamneh,
  • Yarin Attar,
  • Yasmin Netanely-Rimon,
  • Yasmin Jaber,
  • Shahd Yacoub,
  • Or Saar,
  • Olga Georgiev,
  • Paz Kles,
  • Nadeem Darawshi,
  • Reem Bsoul,
  • Adina Heinberg,
  • Luba Eli-Berchoer,
  • Hagit Shapiro,
  • Eran Elinav,
  • Asaf Wilensky,
  • Avi-Hai Hovav

摘要

Mucosal homeostasis after birth depends on coordinated interactions between the microbiota and the immune system, with barrier tissues employing distinct mechanisms. Here, we show that maternal Immunoglobulin G (IgG), transferred both in utero and via breastfeeding, reaches the murine neonatal salivary glands and is secreted into saliva, where it recognizes maternal oral microbes and regulates colonization. Offspring lacking in utero-derived IgG show heightened salivary T- and B-cell activation, followed by alterations in the IgG/IgA balance in adult saliva. While postnatal microbiota is essential for priming salivary adaptive immunity, perinatal IgG intrinsically restrains the adaptive responses independent of microbial load. In utero-derived IgG further shapes adult gingival immunity and limits destructive inflammation in murine periodontitis. By contrast, breast milk antibodies promote timely and proper epithelial maturation, a process dependent on microbial load. Thus, we uncover distinct yet complementary roles of pre- and postnatal maternal antibodies in governing oral immune development and long-term protection against oral disease.