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<p>Electron-spin dynamics represent an additional dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (<sub>C</sub>Au) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and <sub>C</sub>Au, we demonstrate that left-handed <sub>C</sub>Au (Lh-<sub>C</sub>Au) enhances, whereas right-handed <sub>C</sub>Au (Rh-<sub>C</sub>Au) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we engineer molecularly imprinted <sub>C</sub>Au (<sub>C</sub>Au@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model (male DBA/1 J mice). Treatment with Rh-<sub>C</sub>Au@MIP significantly reduces prostaglandin E<sub>2</sub> secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.</p>

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Spin-driven enantioselective regulation of cyclooxygenase-2 activity for rheumatoid arthritis therapy via chiral gold nanohelices

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Jiao Yan,
  • Lai Liu,
  • Zhihao Chen,
  • Qian Zhao,
  • Xiaoqing Han,
  • Yanjing Wang,
  • Zhengzhi Mu,
  • Xingbo Wang,
  • Panpan Song,
  • Yaqing Kang,
  • Weijie Lu,
  • Ai-Min Guo,
  • Qing-Feng Sun,
  • Haiyuan Zhang

摘要

Electron-spin dynamics represent an additional dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and CAu, we demonstrate that left-handed CAu (Lh-CAu) enhances, whereas right-handed CAu (Rh-CAu) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we engineer molecularly imprinted CAu (CAu@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model (male DBA/1 J mice). Treatment with Rh-CAu@MIP significantly reduces prostaglandin E2 secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.