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<p>Monitoring neural population activity at single-cell resolution is essential for fundamental research and clinical innovation. However, translating advanced recording techniques from animal models to humans remains a challenge. Flexible neural electrodes have emerged as powerful tools for large-scale single-unit recordings due to their biocompatibility and high recording density. Here, we demonstrate reliable, high-density single-unit recordings during intraoperative procedures in human patients using ultra-Flexible Implantable Neural Electrode (uFINE) arrays. The uFINE array exhibited sufficient mechanical robustness to maintain structural integrity throughout surgical operations. We successfully recorded 719 single units from 11 patients, with up to 135 single units simultaneously recorded. The flexibility of uFINE array minimized signal disturbances from brain pulsations, enabling stable and continuous single-unit detection. Stimulus and response tuning were observed at the level of individual neurons in awake patients.</p>

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Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月13日

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  • Shun Wu,
  • Zhiqiang Yan,
  • Cen Kong,
  • Xiaofan Jiang,
  • Qiufeng Dong,
  • Youkun Qian,
  • Guangyuan Chen,
  • Beibei Chen,
  • Chi Ren,
  • Junfeng Lu,
  • Xia Li,
  • Zhengtuo Zhao,
  • Xue Li

摘要

Monitoring neural population activity at single-cell resolution is essential for fundamental research and clinical innovation. However, translating advanced recording techniques from animal models to humans remains a challenge. Flexible neural electrodes have emerged as powerful tools for large-scale single-unit recordings due to their biocompatibility and high recording density. Here, we demonstrate reliable, high-density single-unit recordings during intraoperative procedures in human patients using ultra-Flexible Implantable Neural Electrode (uFINE) arrays. The uFINE array exhibited sufficient mechanical robustness to maintain structural integrity throughout surgical operations. We successfully recorded 719 single units from 11 patients, with up to 135 single units simultaneously recorded. The flexibility of uFINE array minimized signal disturbances from brain pulsations, enabling stable and continuous single-unit detection. Stimulus and response tuning were observed at the level of individual neurons in awake patients.