Scholarlink

<p>Catalytic carbon-carbon bond-forming reactions provide the basis for synthetic organic chemistry. To move towards a circular carbon economy, it is imperative to efficiently convert sustainable and inexpensive starting materials, e.g. broadly available renewable feedstocks, in an economically viable and practical manner. In this work&#xa0;, we present a method for the atom-efficient and “waste-free” construction of C-C bonds in ketones with alcohols, including lignin-derived compounds. The broad applicability of this&#xa0;protocol is based on the development of a novel heterogeneous cobalt-based single atom catalyst, which is produced by subjecting a cobalt-poly(p-phenylenediamine)-silica template to pyrolysis and subsequently removing residual silica. The most effective catalyst material consists of isolated cobalt atoms with Co-N<sub>4</sub> active sites dispersed on mesoporous carbon. The resulting material is both highly stable and reusable. The presented method facilitates the general and selective C-alkylation of aromatic, heterocyclic, and aliphatic ketones, as well as secondary alcohols. Applications include the functionalization of bioactive molecules and the preparation of pharmaceutical drugs and valuable methylated compounds. The value of the cobalt-single atom catalyst is further demonstrated in the industrially relevant C-alkylation of KA oil.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A universal atomically dispersed cobalt catalyst for alkylation of ketones alcohols and lignin-derived compounds

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月4日

查看全文
  • Zhuang Ma,
  • Binyu Zhang,
  • Yanbin Cui,
  • Changyue Ren,
  • Xinmin Li,
  • Rajenahally V. Jagadeesh,
  • Matthias Beller

摘要

Catalytic carbon-carbon bond-forming reactions provide the basis for synthetic organic chemistry. To move towards a circular carbon economy, it is imperative to efficiently convert sustainable and inexpensive starting materials, e.g. broadly available renewable feedstocks, in an economically viable and practical manner. In this work , we present a method for the atom-efficient and “waste-free” construction of C-C bonds in ketones with alcohols, including lignin-derived compounds. The broad applicability of this protocol is based on the development of a novel heterogeneous cobalt-based single atom catalyst, which is produced by subjecting a cobalt-poly(p-phenylenediamine)-silica template to pyrolysis and subsequently removing residual silica. The most effective catalyst material consists of isolated cobalt atoms with Co-N4 active sites dispersed on mesoporous carbon. The resulting material is both highly stable and reusable. The presented method facilitates the general and selective C-alkylation of aromatic, heterocyclic, and aliphatic ketones, as well as secondary alcohols. Applications include the functionalization of bioactive molecules and the preparation of pharmaceutical drugs and valuable methylated compounds. The value of the cobalt-single atom catalyst is further demonstrated in the industrially relevant C-alkylation of KA oil.