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<p>The increasing prevalence of cardiovascular diseases and haemodialysis access drive high clinical demand for vascular grafts. Bioinert synthetic and decellularized or cryopreserved artery grafts exhibit poor regeneration and associated complications. Here, we present an approach that combines in vivo bioengineering and decellularization to prepare polycaprolactone skeleton-reinforced biotubes (dPB), which demonstrate appropriate mechanical strength, anti-kinking properties, resistance to repeat puncture, and are compatible with long-term storage at 4 °C. The loose and porous microstructure and immunomodulatory bioactivity of dPB induce rapid recellularization and promote pro-regenerative M2 macrophage polarization, which together facilitate remodelling to native artery-like tissue. In porcine coronary artery bypass grafting, canine carotid artery replacements and arteriovenous grafting models, ovine-derived dPB show high patency without dilatation, calcification and intimal hyperplasia. In summary, dPB offer a readily available and pro-regenerative vascular graft with a broad application prospect for patients with unavailable autologous vessels.</p>

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Reinforced biotubes as readily available and regenerative vascular grafts

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月23日

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  • Quhan Cheng,
  • Dengke Zhi,
  • Adam C. Midgley,
  • Ye Wan,
  • Yi Li,
  • Ruixin Zhang,
  • Xiaorui Ping,
  • Baofa Sun,
  • Yu Shi,
  • Jiayao Zheng,
  • Su Zhang,
  • Boxin Liu,
  • Tingting Wei,
  • Qiuying Zhang,
  • Tengzhi Ma,
  • Muhammad Rafique,
  • Qining Fu,
  • Xianhui Liang,
  • Beat H. Walpoth,
  • Pei Wang,
  • Yu Zhao,
  • Ting Wang,
  • Qiang Zhao,
  • Xiaofeng Ye,
  • Meifeng Zhu,
  • Deling Kong,
  • Kai Wang

摘要

The increasing prevalence of cardiovascular diseases and haemodialysis access drive high clinical demand for vascular grafts. Bioinert synthetic and decellularized or cryopreserved artery grafts exhibit poor regeneration and associated complications. Here, we present an approach that combines in vivo bioengineering and decellularization to prepare polycaprolactone skeleton-reinforced biotubes (dPB), which demonstrate appropriate mechanical strength, anti-kinking properties, resistance to repeat puncture, and are compatible with long-term storage at 4 °C. The loose and porous microstructure and immunomodulatory bioactivity of dPB induce rapid recellularization and promote pro-regenerative M2 macrophage polarization, which together facilitate remodelling to native artery-like tissue. In porcine coronary artery bypass grafting, canine carotid artery replacements and arteriovenous grafting models, ovine-derived dPB show high patency without dilatation, calcification and intimal hyperplasia. In summary, dPB offer a readily available and pro-regenerative vascular graft with a broad application prospect for patients with unavailable autologous vessels.