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<p>The retrosplenial cortex (RSC) integrates sensory and mnemonic information to support spatial orientation and navigation, yet how visuospatial processing differs across its subregions remains unclear. Here, we combined cellular imaging in navigating mice with brain-wide anatomical input tracing&#xa0;to characterize how multimodal sensory and positional signals are integrated along the anterior–posterior axis of dorsal RSC. We identified consistent&#xa0;differences between anterior and posterior subregions in both functional response properties and long-range connectivity. Anterior RSC neurons displayed sharper and more reliable position tuning during tactile-cued navigation and preferential sensitivity to fast, low–spatial-frequency visual motion. In contrast, posterior RSC neurons showed broader position selectivity, stronger responses to slow, high–spatial-frequency visual patterns, and enhanced tuning in visually immersive virtual environments. Consistent with these differences, anterior RSC received denser projections from motor, somatosensory, and parietal areas, whereas posterior RSC received stronger input from&#xa0;primary and posteromedial visual cortices. Together, these findings identify&#xa0;an anterior–posterior functional gradient in RSC, with&#xa0;subregions&#xa0;differing in how they integrate sensory and positional signals&#xa0;during&#xa0;navigation.</p>

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Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月25日

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  • Yu-Ting Wei,
  • João Couto,
  • Fabian Kloosterman,
  • Vincent Bonin

摘要

The retrosplenial cortex (RSC) integrates sensory and mnemonic information to support spatial orientation and navigation, yet how visuospatial processing differs across its subregions remains unclear. Here, we combined cellular imaging in navigating mice with brain-wide anatomical input tracing to characterize how multimodal sensory and positional signals are integrated along the anterior–posterior axis of dorsal RSC. We identified consistent differences between anterior and posterior subregions in both functional response properties and long-range connectivity. Anterior RSC neurons displayed sharper and more reliable position tuning during tactile-cued navigation and preferential sensitivity to fast, low–spatial-frequency visual motion. In contrast, posterior RSC neurons showed broader position selectivity, stronger responses to slow, high–spatial-frequency visual patterns, and enhanced tuning in visually immersive virtual environments. Consistent with these differences, anterior RSC received denser projections from motor, somatosensory, and parietal areas, whereas posterior RSC received stronger input from primary and posteromedial visual cortices. Together, these findings identify an anterior–posterior functional gradient in RSC, with subregions differing in how they integrate sensory and positional signals during navigation.