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<p>GABAergic medial septal neurons play a key role in regulating hippocampus-dependent spatial memory, but the underlying mechanisms are not yet fully understood. In male mice, we establish an object-place recognition impairment model using an acute sleep deprivation protocol. Here we show that parvalbumin-positive neurons in the medial septum regulate object-location memory specificity during encoding by modulating hippocampal place cell population activity. Using in vivo electrophysiology combined with optogenetics, we characterize the role of medial septal parvalbumin-positive neurons in object-place recognition during memory encoding. Preference for objects relocated to novel positions parallels directional shifts in place fields of remapping neuronal populations, as well as decreased co-activity among place cells in dorsal CA1 during the encoding phase. Activating medial septal parvalbumin-positive neurons during memory encoding rescues object-place recognition impairments. These findings suggest that parvalbumin-positive neurons in the medial septum play a causal role in object-place recognition memory.</p>

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Parvalbumin-positive neurons in the medial septum participate in the formation of hippocampal-dependent spatial memory

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月20日

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  • Yawen Zheng,
  • Jifu Tong,
  • Yuanwei Xing,
  • Shan Shao,
  • Naizheng Liu,
  • Shuting Liu,
  • Jiao Wu,
  • Wang Yin,
  • Jiaxin Wang,
  • Shulu Yuan,
  • Kun Cui,
  • Xuetao Qi,
  • Shuang Cui,
  • You Wan,
  • Ming Yi

摘要

GABAergic medial septal neurons play a key role in regulating hippocampus-dependent spatial memory, but the underlying mechanisms are not yet fully understood. In male mice, we establish an object-place recognition impairment model using an acute sleep deprivation protocol. Here we show that parvalbumin-positive neurons in the medial septum regulate object-location memory specificity during encoding by modulating hippocampal place cell population activity. Using in vivo electrophysiology combined with optogenetics, we characterize the role of medial septal parvalbumin-positive neurons in object-place recognition during memory encoding. Preference for objects relocated to novel positions parallels directional shifts in place fields of remapping neuronal populations, as well as decreased co-activity among place cells in dorsal CA1 during the encoding phase. Activating medial septal parvalbumin-positive neurons during memory encoding rescues object-place recognition impairments. These findings suggest that parvalbumin-positive neurons in the medial septum play a causal role in object-place recognition memory.