Scholarlink

<p>Current animal models of HIV-1 infection&#xa0;are either immunocompromised or rely on proxy viruses instead of HIV-1. Here, we establish an immunocompetent animal model for CXCR4-tropic HIV-1 in owl monkeys (<i>Aotus nancymaae</i>). Through analysis of 191 owl monkeys, genetic characterization and functional testing demonstrate that CD4 and Tetherin in this species support HIV-1 replication. Although owl monkeys do carry restrictive TRIMCyp and APOBEC3G alleles, small changes to the HIV-1 genome allow the virus to overcome these barriers. The resulting virus remains 93% wildtype HIV-1 in sequence. Fully immunocompetent owl monkeys can be infected with this virus, recapitulating key aspects of HIV-1 infection in humans: an initial surge of virus replication, subsequent establishment of a durable set point viremia, seroconversion, and the formation of a viral reservoir. The owl monkey model broadens the experimental options for HIV-1 research, and future studies will explore its utility for CCR5-tropic virus strains.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

CXCR4-tropic HIV-1 infection in an immunocompetent monkey model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月9日

查看全文
  • Nicholas R. Meyerson,
  • Vanessa L. Bauer,
  • Will T. Fattor,
  • Cody J. Warren,
  • Arturo Barbachano-Guerrero,
  • Melisa J. Weiss,
  • Obaiah Dirasantha,
  • Bridget L. Burris,
  • Adetunji S. Adesina,
  • Joseph L. Timpona,
  • Emily R. Feldman,
  • Ryan T. Fahy,
  • Paul Gendler,
  • Ava Fainberg,
  • Pramod N. Nehete,
  • Kathryn A. Shelton,
  • Analy Galvan,
  • George W. Tustin,
  • Paul J. Koehle,
  • Maria D. Salinas,
  • Omar Davila,
  • Elizabeth I. Lindemann,
  • Sean E. Clark,
  • Mackenzie L. Garnett,
  • C. Todd DeMarco,
  • Salvatore R. Scianna,
  • Thomas N. Denny,
  • Jens H. Kuhn,
  • Pyone P. Aye,
  • Ron S. Veazey,
  • Sarah M. Kezar,
  • Gregory K. Wilkerson,
  • Sara L. Sawyer

摘要

Current animal models of HIV-1 infection are either immunocompromised or rely on proxy viruses instead of HIV-1. Here, we establish an immunocompetent animal model for CXCR4-tropic HIV-1 in owl monkeys (Aotus nancymaae). Through analysis of 191 owl monkeys, genetic characterization and functional testing demonstrate that CD4 and Tetherin in this species support HIV-1 replication. Although owl monkeys do carry restrictive TRIMCyp and APOBEC3G alleles, small changes to the HIV-1 genome allow the virus to overcome these barriers. The resulting virus remains 93% wildtype HIV-1 in sequence. Fully immunocompetent owl monkeys can be infected with this virus, recapitulating key aspects of HIV-1 infection in humans: an initial surge of virus replication, subsequent establishment of a durable set point viremia, seroconversion, and the formation of a viral reservoir. The owl monkey model broadens the experimental options for HIV-1 research, and future studies will explore its utility for CCR5-tropic virus strains.