<p>The topological Hall effect, driven by the exchange interaction between conduction electrons and topological magnetic textures such as skyrmions, is a powerful probe for investigating the topological properties of magnetic materials. Typically, this phenomenon arises in systems with broken global inversion symmetry, where Dzyaloshinskii-Moriya interactions stabilize such textures. Here, we report the discovery of an emergent giant topological Hall effect in the twisted Fe₃GeTe₂ metallic system, which notably preserves the general global inversion symmetry. This effect manifests exclusively within a narrow window of “magic” twist angles ranging from 0.45° to 0.75°, while it is absent outside of that range, highlighting its unique and emergent nature. Micromagnetic simulations reveal that this topological Hall effect originates from a skyrmion lattice induced by alternating in-plane and layer-contrasting Dzyaloshinskii-Moriya interactions that result from local inversion symmetry breaking. Our findings underscore twisted Fe₃GeTe₂ as a versatile platform for engineering and controlling topological magnetic textures in metallic twisted van der Waals magnets, thereby opening up new avenues for next-generation spintronic devices.</p>