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<p>Pregnancy and aging are associated with stress on the body and show multi-system physiological changes. We asked whether we can learn about aging from the changes in pregnancy. To do so, we analyzed weekly cross-sectional data on 70 lab tests from 300,000 pregnancies and 1.4 million non-pregnant females aged 20–89. Using a biological age model trained on non-pregnant females, we observed that pregnant females’ apparent age dropped by 5 years in the first trimester, rose by 20 years toward delivery, and recovered postpartum. Pregnancy complications increased apparent age by 2–6 years. Certain systems exhibited apparent rejuvenation – opposite trends in pregnancy vs aging – including renal, iron, and most liver tests. Others, such as coagulation, thyroid, muscle, and metabolism, showed apparent aging. Notably, the aging-like mechanisms of pregnancy differed from normal aging, suggesting superficial similarity, whereas the rejuvenation-like mechanisms may offer clues for slowing aspects of biological aging.</p>

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Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Ron Moran,
  • Glen Pridham,
  • Yoel Toledano,
  • Uri Alon

摘要

Pregnancy and aging are associated with stress on the body and show multi-system physiological changes. We asked whether we can learn about aging from the changes in pregnancy. To do so, we analyzed weekly cross-sectional data on 70 lab tests from 300,000 pregnancies and 1.4 million non-pregnant females aged 20–89. Using a biological age model trained on non-pregnant females, we observed that pregnant females’ apparent age dropped by 5 years in the first trimester, rose by 20 years toward delivery, and recovered postpartum. Pregnancy complications increased apparent age by 2–6 years. Certain systems exhibited apparent rejuvenation – opposite trends in pregnancy vs aging – including renal, iron, and most liver tests. Others, such as coagulation, thyroid, muscle, and metabolism, showed apparent aging. Notably, the aging-like mechanisms of pregnancy differed from normal aging, suggesting superficial similarity, whereas the rejuvenation-like mechanisms may offer clues for slowing aspects of biological aging.