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<p>Elevated sugar intake has been linked to poor cardiovascular health, but the effects of early-life sugar restriction on the lifelong risk of heart failure remain unclear. Using the end of sugar rationing in the United Kingdom in 1953 as a natural experiment, we classify participants in the UK Biobank by birth timing to define early-life exposure to sugar rationing. Here we show that individuals exposed to early-life sugar rationing exhibit an approximately 14% lower risk of heart failure and develop the condition about 2.6 years later than those unexposed. Longer exposure is associated with stronger effects, and population-level estimates suggest that around 4–5% of heart failure cases may be attributable to the absence of early-life sugar restriction. Genetic susceptibility does not modify these associations but acts additively. These findings underscore the long-term importance of early-life sugar exposure for heart failure, and further studies are warranted.</p>

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Sugar rationing during the first 1000 days of life and lifelong risk of heart failure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Haoxian Tang,
  • Xuan Zhang,
  • Jingtao Huang,
  • Xiaojing Chen,
  • Jianan Hong,
  • Hanyuan Lin,
  • Cuihong Tian,
  • Luo Nan,
  • Mengyue Lin,
  • Qinglong Yang,
  • Shiwan Wu,
  • Pan Chen,
  • Jiasheng Wen,
  • Liwen Jiang,
  • Youti Zhang,
  • Yali Wang,
  • Xuerui Tan,
  • Yequn Chen

摘要

Elevated sugar intake has been linked to poor cardiovascular health, but the effects of early-life sugar restriction on the lifelong risk of heart failure remain unclear. Using the end of sugar rationing in the United Kingdom in 1953 as a natural experiment, we classify participants in the UK Biobank by birth timing to define early-life exposure to sugar rationing. Here we show that individuals exposed to early-life sugar rationing exhibit an approximately 14% lower risk of heart failure and develop the condition about 2.6 years later than those unexposed. Longer exposure is associated with stronger effects, and population-level estimates suggest that around 4–5% of heart failure cases may be attributable to the absence of early-life sugar restriction. Genetic susceptibility does not modify these associations but acts additively. These findings underscore the long-term importance of early-life sugar exposure for heart failure, and further studies are warranted.